In addition, other pathways with high enrichment consisted of interleukin-2 signalling, which has been reported to be a key signalling pathway required for the survival of leukaemia initiating cells in chronic myeloid leukaemia (Kobayashi et al. 2014); moreover, this has been shown to be an early change. This evidence concerns the gene IL2 and chronic myelogenous leukemia, BCR-ABL1 positive.