In FTD, screening of 752 microRNAs in polymer-precipitated EVs from CSF identified two miRNAs that were decreased in symptomatic versus pre-symptomatic states: miR-204-5p in GRN, C9orf72 and sporadic FTD, and miR-632 in GRN and sporadic disease only [210]. The gene discussed is GRN; the disease is frontotemporal dementia.