Whilst direct evidence for a similar mechanism in TDP-43 proteinopathies is limited, in plasma-derived EVs from LATE participants, Winston et al. find higher levels of TDP-43 in EV prepared using SLC1A3 (astrocytic-enriched) and TMEM119 (microglial-enriched) immunocapture, hinting at a possible role for glial-mediated EV transfer of TDP-43 that requires further exploration [46]. Here, TARDBP is linked to proteostasis deficiencies.