Analysis of brain and spinal cord tissue from ALS and FTD cases characteristically show that TDP-43 aggregates are found in the form of a high-molecular weight smear (from 55 kDa up to at least 200 kDa), and truncated C-terminal fragments (CTFs) that migrate as a 25 kDa band in immunoblots and typically exhibit extensive phosphorylation and ubiquitination [15]. Here, TARDBP is linked to amyotrophic lateral sclerosis.