Of note, several of the differently expressed miRNAs such as miR-223-3p, miR-1275, miR-4301, miR-449a, miR-7-5p, and miR-20a-5p in Apo-EVs from the cisplatin-treated cells have been reported to act as powerful regulators of cell proliferation and survival in different cancer and non-cancer cells [22–25, 36–38]. Here, AOPEP is linked to cancer.