A cis-acting germline alteration located in the 5’ UTR of BRCA1 gene (c.-107A > T, rs2154580237), has been previously identified in 2018 in two British families and was found to segregate with BRCA1 promoter hypermethylation, predisposing carriers to breast and ovarian cancer [12]. This evidence concerns the gene BRCA1 and ovarian carcinoma.