Emerging evidence suggests that METTL3 plays a crucial role in cancer development, acting either as an oncogene or tumor suppressor gene (Zeng et al. 2020), for instance: METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression (Wang et al. 2020a, b, c). The gene discussed is METTL3; the disease is gastric cancer.