HMGB1 and ischemia: Neutrophil extracellular traps mediate cardiomyocyte ferroptosis via the Hippo-Yap pathway to exacerbate doxorubicin-induced cardiotoxicity (Zhao et al. 2024), where HMGB1 acts as an iron apoptosis inducer by upregulating ferroptosis in astrocytes, thereby aggravating the acute injury after ischemia in the brain (Davaanyam et al. 2023).