Specific investigations have revealed that FBW7 enhances the cytotoxic effect of gemcitabine by activating both ferroptosis and apoptosis (Ye et al. 2021), while SLC38A5 regulates ferroptosis to overcome gemcitabine resistance in pancreatic cancer (Kim et al. 2023).In recent years, numerous studies have highlighted the role of HMGB1 in regulating cell ferroptosis (Han et al. 2024; Liu et al. 2024). This evidence concerns the gene HMGB1 and pancreatic neoplasm.