METTL3 and familial pancreatic carcinoma: Moreover, accumulating evidence suggests that elevated levels of O-GlcNAcylation are closely associated with pancreatic cancer progression, metastasis and recurrence, ECM remodeling, and immunotherapy resistance (Sharma et al. 2020; Shang et al. 2021).In our study on pancreatic cancer, we observed a regulatory relationship between METTL3 expression and the extent of O-GlcNAcylation modification.