In pancreatic ductal adenocarcinoma, Targeting the MCP-GPX4/HMGB1 Axis for Effectively Triggering Immunogenic Ferroptosis (Li et al. 2024a, b); N6F11 treatment caused ferroptotic cancer cell death that initiated HMGB1-dependent antitumor immunity mediated by CD8 + T cells (Li et al. 2023a, b). Here, HMGB1 is linked to pancreatic ductal adenocarcinoma.