METTL3 and familial pancreatic carcinoma: Since O-GlcNAcylation usually affects protein stability, we downloaded the expression of METTL3 and OGT proteins in pancreatic cancer patients from the Proteomic Data Commons and plotted a correlation curve, which showed that OGT protein expression and METTL3 protein expression were positively correlated in pancreatic cancer (Fig. S7E).