HMGB1 and familial pancreatic carcinoma: In order to determine the downstream ferroptosis target regulated by METTL3, we used a Venn diagram showing differential genes obtained from GSE146806 analysis, correlation genes of METTL3 in pancreatic cancer obtained from UALCAN, target genes from RM2Target database, and the genes corresponding to METTL3 binding RNA peaks in GSE13306 and ferroptosis-related genes to obtain HMGB1 (Fig. 3B).