For instance: promotion of pancreatic tumor growth by regulating malate dehydrogenase 1 through O-GlcNAcylation has been reported (Zhu et al. 2022); facilitation of ferroptosis in mesenchymal pancreatic cancer cells via ZEB1’s O-GlcNAcylation has also been observed (Wang et al. 2022); additionally, O-GlcNAcylation-mediated stabilization of SIRT7 promotes pancreatic cancer progression by disrupting the SIRT7-REGγ interaction (He et al. 2022). The gene discussed is MDH1; the disease is familial pancreatic carcinoma.