Among them, M1-type polarisation is driven by activation of IFN-γ and LPS (Lipopolysaccharide), which confers pro-inflammatory and anti-tumour activities to TAMs, whereas IL-4, IL-10, and IL-13 induce M2-type polarisation, forming a pro-carcinogenic microenvironment with immune-suppressive, pro-angiogenic and metastasis-promoting effects [40, 41]. The gene discussed is IL10; the disease is neoplasm.