The functions of chemokines in TME show remarkable duality: while CCL22 inhibits anti-tumour immunity by recruiting Tregs through a CCR4-dependent pathway, CXCL10 enhances immunosurveillance by recruiting CXCR3+ effector T-cells, a paradoxical effect that may stem from the spatial and temporal heterogeneity of the cytokine concentration gradient and the expression profile of the receptor within the microenvironment [67]. Here, CXCL10 is linked to neoplasm.