CD4 and neoplasm: Key components of TME include 1) Cancer-Associated Fibroblasts (CAFs); 2) Tumor-Infiltrating Immune Cells (neutrophils, Macrophages, Dendritic Cells (DCs), Natural Killer Cells (NKs), Myeloid-Derived Suppressor Cells (MDSCs), and CD8+ T Cells, CD4+ T Cells, Tregs, and B Cells); 3) ECM; 4) Blood Vessels; and 5) Cytokines.