Celastrus orbiculatus extract (COE), a mixture of 11 terpenoids isolated from the herb Celastrus orbiculatus vine, can block TGF-β 1-induced VM formation and HCC tumour growth by down-regulating Notch1 signaling and is considered superior to other anti-angiogenic drugs due to its It is considered a promising candidate for HCC treatment because of its superiority over other anti-angiogenic drugs [134]. Here, NOTCH1 is linked to hepatocellular carcinoma.