Experimental studies showed that baicalin significantly reversed the immunosuppressive microenvironment by inducing immunogenic cell death (ICD) in HCC cells and activating adaptive immune response; meanwhile, it alleviated the inhibitory effect of the acidic microenvironment on lymphocytes by inhibiting the activity of lactate dehydrogenase A (LDHA) and lowering the concentration of lactate in TME [153, 154]. The gene discussed is LDHA; the disease is hepatocellular carcinoma.