NFKB1 and glucose metabolism disease: Since NF-κb (Sies et al. 2024), apoptosis (Sies et al. 2024) and profibrotic (Gonzalez-Gonzalez et al. 2017) signaling pathways are strongly correlated with oxidative stress, we reasoned that oxidative stress is a key mechanism for Tac-induced glucose metabolism disorder.