Bioinformatics analysis revealed a consistent elevation in PIEZO1 mRNA in lesional skin from psoriatic patients relative to controls (GSE30999: P < 0.001 and GSE121212: P < 0.05), as presented in Fig. 1D. Extending our investigation to an in vivo context, we employed an IMQ-induced mouse model resembling the human condition of psoriasis. The gene discussed is PIEZO1; the disease is psoriasis.