Additionally, visual acuity may be less sensitive than low contrast acuity in detecting deficits in optic neuritis; visual field assessments were not performed; and there is an inherent floor effect in OCT measurements, whereby patients with MOGAD and AQP4-NMOSD may exhibit severely thinned RNFL/GCIPL despite having contrasting visual acuity outcomes. The gene discussed is AQP4; the disease is optic neuritis.