We confirmed these results using a different set of markers to distinguish progenitor-like cells (Texprog1 and Texprog2) from exhausted intermediate (Texint) and terminally exhausted cells (Texterm), as described by Beltra et al (Beltra et al, 2020) (Appendix Fig. S3F–J) and observed a dramatic reduction in the frequences of Ly108−CD69− Texint cells (Appendix Fig. S3F,G) and a significant increase in the percentage of Ly108−CD69+ Texterm cells (Appendix Fig. S3F,H) in the Irf5−/− p14 group compared with WT p14 throughout the course of infection. This evidence concerns the gene IRF5 and infection.