Interferon Regulatory Factor 5 (IRF-5), originally characterized as a transcription factor downstream of the Type I interferon signaling pathway in innate immune cells (Barnes et al, 2001), has been reported to play an essential role in tumor suppression (Bi et al, 2014), cell cycle regulation (Barnes et al, 2003), induction of apoptosis (Hu and Barnes, 2009), regulation of proinflammatory cytokines in myeloid lineages (Takaoka et al, 2005), M1 macrophage polarization (Krausgruber et al, 2011), and regulation of plasma cell development (De et al, 2017). This evidence concerns the gene IRF5 and neoplasm.