Naive CD8 T cells purified from these mice and from the IRF-5 sufficient, Cre- p14 control mice (Irf5flox/flox x CMV-Cre−p14; herein called as WT p14) were then adoptively transferred into CD45.1 congenic mice a day prior to infection with LCMV Cl13 (Appendix Fig. S1C). Here, CD8A is linked to infection.