In other diseases, particularly liver cancer, NRF2 and the WNT pathway exhibit interplay, where WNT3A stimulates NRF2, and NRF2 either stabilizes β-CATENIN or promotes its transcription to activate the WNT pathway (Fragoulis et al, 2022; Rada et al, 2015). This evidence concerns the gene NFE2L2 and liver cancer.