NOTCH1 and fatty liver disease: Furthermore, Treg depletion in macrophage-specific Notch1-deficient mice significantly abolished the ameliorative effect of macrophage Notch 1 deletion on hepatic steatosis during MASLD development [78], highlighting the crucial role of the Notch1/exosomal miR-142a-3p/TGFβR1 pathway in macrophages by regulating Treg differentiation during MASLD progression.