TREM2 and metabolic dysfunction-associated steatotic liver disease: Importantly, the livers of patients with MASLD and mouse MASLD models display a distinct population of TREM2+ macrophages, and Trem2 deficiency in macrophages exacerbates mitochondrial dysfunction in hepatocytes by releasing exosomes containing high levels of miR-106b-5p, leading to MASLD progression [38].