Conversely, while secondary M/D-driven carcinomas evolving in Mlkl-/- mice grew less rapidly compared to the same tumors progressing in WT mice (p value: <0.0001), the contrary was true for secondary M/D-driven tumors developing in Ppif−/− mice (p value: 0.0003) (Fig. 2C). Here, MLKL is linked to carcinoma.