In line with this notion, the Ripk3−/− and even more so the Mlkl−/− genotype were associated with an extension in TTD (median TTD: 25 and 30 days, respectively; p value: 0.0084 and 0.0035, respectively) (Fig. 3A), largely reflecting the reduced speed of tumor progression at primary disease sites (Fig. 1B) in the context of limited alterations in TT2 and secondary tumor growth (Fig. 2A–C). The gene discussed is RIPK3; the disease is neoplasm.