Cardiac glycoside has also been reported to suppress cell migration and invasion of lung cancer cells by inhibiting the ERK signaling pathway (Pongrakhananon et al, 2013), as well as reduce inflammation in a rheumatoid arthritis model by inhibiting the NF-κB signaling pathway (Menger et al, 2012). This evidence concerns the gene NFKB1 and rheumatoid arthritis.