BAG3 and Charcot-Marie-Tooth disease: CMT1A attributable to PMP22 duplication is the most common form of CMT, and patients show early involvement of the anterior compartment of the leg and the gastrocnemius muscles, with sparing of the soleus and thigh muscles until late stages of the disease.30  BAG3-NMD muscle involvement on MRI would, in turn, resemble more closely that of pure motor neuropathies or dHMN, where soleus muscle involvement is an early phenomenon across most dHMN genes.31 However, gastrocnemius muscles are also frequently involved in dHMN and, as we show, are spared in BAG3 patients.