BAG3 and neuromuscular disease: Autosomal dominant variants in the BAG3 gene are associated with dilated cardiomyopathy (DCM) (OMIM #613881).5 Less frequently, de novo or autosomal dominant variants can be associated with a wider spectrum of neuromuscular diseases (NMDs) encompassing myofibrillar myopathy (MFM) (OMIM #612954) and Charcot–Marie–Tooth disease (CMT).6,7