Our study found a correlation between the C allele of IGFBP-3 A-202C (SNP rs2854744) with circulating IGFBP-3 levels (rs = 0.164, p = 0.003), in which its serum levels were associated with an increased risk of breast cancer (OR = 1.154; 95%CI 0.982, 1.357, p < 0.25) (data not shown). This evidence concerns the gene IGFBP3 and breast cancer.