This study provides novel insights into IGFBP-3 A-202C (rs2854744) gene polymorphism and its association with serum levels of IGFBP-3 and IGF-1, suggesting its potential as a diagnostic marker for early detection, personalized risk assessment, and targeted interventions in high-incidence breast cancer regions such as the Gaza Strip. Here, IGFBP3 is linked to breast cancer.