To the best of our knowledge, this is the first study to elucidate the role of IGFBP-3 A-202C (rs2854744) gene polymorphism and IGF-1 and IGFBP-3 serum levels as biomarkers for early detection of breast cancer among Palestinian women in the Gaza Strip offering insights into its potential as a biomarker for regional breast cancer risk. This evidence concerns the gene IGFBP3 and breast carcinoma.