IGFBP3 and breast cancer: Al-Zahrani et al. also reported that the A allele was associated with increased circulating IGFBP-3 levels, with mean levels of 4.316, 3.941, and 3.614 mg/L for AA, AC, and CC genotypes, respectively, and a decreased breast cancer risk (OR (AA/CC)=0.87; 95%CI 0.77, 0.99, p = 0.03) [18].