For instance, a large case-control study in the UK, including 4,647 breast cancer cases and 4,564 controls, found that the AA genotype of IGFBP-3 rs2854744 was associated with increased circulating IGFBP-3 levels and a modestly reduced risk of breast cancer (OR = 0.87; 95% CI 0.77, 0.99, p = 0.03) [18]. This evidence concerns the gene IGFBP3 and breast cancer.