These coding SNVs/INDELs were enriched in pathways including KEGG Central Carbon Metabolism in Cancer (FDR = 0.0046) and PI3K-Akt Signaling (FDR = 0.029), and the GO molecular function Protein tyrosine phosphatase activity (FDR = 0.022) (S10 Table). Here, PIK3CD is linked to cancer.