TARDBP and amyotrophic lateral sclerosis: For example, the NTD directbinder, nTRD22, ameliorates motor behavior deficits induced by TDP-43overexpression in Drosophila; and ropinirole,an ALS drug currently in clinical trials, improves TDP-43 pathologyin patient-derived iPSC motor neurons indirectly through modulationof the cholesterol biosynthesis pathway.