Next, we tested ketoconazole’s ability to rescueTDP-43 induced neurite loss in a neuronal TDP-43 proteinopathy modelin differentiated Neuro2a (N2a) cells stably overexpressing FL TDP-43-mNg.Neurite outgrowth has been recently used as a robust phenotypic assaythat monitors ALS associated cellular dysfunction and for the discoveryof novel ALS therapeutics. Stable FL TDP-43-mNgexpression reduced neurite outgrowth by roughly 50% compared to naïveN2a cells (Figure A-B). The gene discussed is TARDBP; the disease is proteostasis deficiencies.