SLC12A3 and Hypernatremia: When placed on a K+-deficient diet, where NCC phosphorylation was high and KS-WNK1 dependent (Figure 2), KS-WNK1–KO females exhibited more pronounced hypernatremia, hypokalemia, and reduced urine osmolality compared with WT females (Figure 7, A–C, and Supplemental Tables 2 and 3).