Notably, these AR–/NE+ tumor cells demonstrated morphological features reminiscent of small-cell carcinoma, including high nuclear-to-cytoplasmic ratios, hyperchromatic nuclei, and nuclear molding, whereas the AR+ cells were cytologically consistent with a prostatic adenocarcinoma with open chromatin and prominent nucleoli (Figure 5F and Supplemental Figure 11). This evidence concerns the gene AR and small cell carcinoma.