AR and prostate adenocarcinoma: To delve deeper into the molecular tumor features at the single-cell level, we performed snRNA-seq and snATAC-seq on a prostate tissue specimen from patient 13-084 containing adjacent and intermixed AR+/NE– prostatic adenocarcinoma (ARPC), AR–/NE+ high-grade NEPC, and AR–/NE– sarcomatoid carcinoma (SARC) cell populations (Figure 6D and Supplemental Figure 13).