Interestingly, while there was no significant difference in extent of HIV-1 infection in MDMs derived from younger or older MDMs (Figure 8E and Supplemental Figure 7A), IP-10 production in HIV-infected older MDMs was higher than that observed with HIV-infected MDMs from younger donors (Figure 8F and Supplemental Figure 7B). This evidence concerns the gene CXCL10 and HIV-1 infection.