While knockdown of IRF3, IRF5, or IRF7 expression had no impact on the efficiency of infection establishment (Figure 4E and Supplemental Figure 3I), we observed significant downregulation in IP-10 expression upon IRF5 or IRF3 knockdown and a trend toward significance upon knockdown of IRF7 expression in HIV-infected MDMs (Figure 4F and Supplemental Figure 3J). The gene discussed is IRF3; the disease is infection.