CXCL10 and infection: Similar to findings in MDMs, establishment of productive infection in THP-1/PMA macrophages resulted in robust secretion of IP-10, which was abrogated in the presence of inhibitors that target reverse transcriptase (efavirenz [EFV]), integrase (raltegravir), or viral transcription (spironolactone) (38, 39) (Figure 1B).