CKAP4 and chronic kidney disease: Since both depletion and overexpression of CKAP4 have been shown to affect the microtubular network, and as CKAP4 is also involved in actin regulation, we hypothesized that CKAP4 is essential for maintaining a functional cytoskeleton in podocytes and that loss of CKAP4 contributes to the cytoskeletal dysfunction and podocyte FPE observed in CKD.