Meanwhile, we observed that when KLHL37 was overexpressed in different cancer cells, it promoted the clonogenic ability of these cells, and this enhancement was particularly pronounced in cells with an N-Myc expression background, such as neuroblastoma SH-SY5Y and rhabdomyosarcoma RH30 cells (Figure 1F and Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI176655DS1). This evidence concerns the gene ENC1 and neuroblastoma.