To interrogate PPP flux in immune cells in the context of MS-relevant mouse models, we measured PPP engagement ex vivo in splenocytes harvested at day 16 from mice with myelin oligodendrocyte glycoprotein–experimental autoimmune encephalomyelitis (MOG-EAE) and at week 8 in mice with cuprizone (CUP)-mediated demyelination (5). Here, OMG is linked to myeloid sarcoma.