Inhibition of the PPP also prevented antigen-specific CD8+ T cell–mediated neuronal injury, both in vitro and in a mouse model of demyelination, and antigen-specific CD8+ T cells treated ex vivo with 6AN largely failed to infiltrate the CNS following adoptive transfer in this model, though they survived after transfer and expanded within the CLNs and spleen (Figures 8 and 9, and Supplemental Figure 5). The gene discussed is CD8A; the disease is Peripheral demyelination.