Nonetheless, we have once again identified that THRSP-OE mice, an animal model for ADHD-PI, have impaired dopamine neurotransmission, as evidenced by low D1R binding and dopamine concentrations. Taken together, these results reinforce the relevance of THRSP-OE mice as a robust and mechanistically informative model for investigating the dopaminergic underpinnings of ADHDPI. Here, DRD1 is linked to attention deficit-hyperactivity disorder.