During ozone-induced asthma exacerbation, PVT1 activates the phosphatidylinositol 3-kinase (PI3 K)/AKT/mammalian target of rapamycin (mTOR) pathway by inhibiting the miR-15a-5p pathway, resulting in a reduced Th1/Th2 ratio that facilitates asthma progression. This evidence concerns the gene MTOR and asthma.