PVT1 and systemic lupus erythematosus: SLE + lenti-Pvt1 exerted opposite effects: T-bet (p = 0.0035) and Foxp3 (p = 0.0001) were downregulated, whereas GATA3 (p = 0.0245) and RORγt (p = 0.0428) were amplified (Fig. 4E–H).