Whereas in rheumatoid arthritis, PVT1 knockdown suppressed IL-1β and IL-6 expression, consistent with our findings of significantly reduced IL-6 expression in the SLE + si-Pvt1 group, while also activating apoptosis in fibroblast-like synoviocytes [36]. The gene discussed is PVT1; the disease is systemic lupus erythematosus.