To systematically investigate the role of lncRNA PVT1 in SLE pathogenesis, CD4+ T cell dysregulation, and its interaction with miR-30e-5p, we generated lentiviral constructs for PVT1 knockdown and overexpression in 40 female MRL-Fas(lpr) mice. Here, PVT1 is linked to systemic lupus erythematosus.