Our findings indicate a specific upregulation of lncRNA PVT1 expression in female SLE patients, the influence of targeting lncRNA PVT1 on Th1/Th2 and Th17/Treg homeostasis, and the potential significance of lncRNA PVT1/miRNA-30e-5p in modulating immune responses in SLE through a ceRNA mechanism. This evidence concerns the gene PVT1 and systemic lupus erythematosus.