PVT1 and systemic lupus erythematosus: Through the construction of SLE + si-Pvt1 and SLE + lenti-Pvt1 MRL/lpr mice, we additionally observed an inverse correlation between the expression patterns of lncRNA PVT1 and miRNA-30e-5p, along with the impact of lncRNA PVT1 on the phenotype of MRL/lpr mice and the imbalance of Th1/Th2 and Th17/Treg.