PVT1 and systemic lupus erythematosus: Conversely, Pvt1 overexpression (SLE + lenti-Pvt1) decreased Th1 (p = 0.0045) and Treg (p = 0.0163) frequencies, respectively, but elevated Th2 (p = 0.0261) and Th17 (p = 0.0120) proportions.