PVT1 and systemic lupus erythematosus: At the transcriptional level, SLE + si-Pvt1 upregulated Th1 master regulator T-bet (p = 0.0052) and Treg-specific Foxp3 (p = 0.0035), while suppressing Th2-associated GATA3 (p = 0.0195) and Th17-driving RORγt (p = 0.0274).