Compared to the Lenti-Ctrl group, Pvt1 knockdown (SLE + si-Pvt1) increased Th1 (CD4+IFN-γ+) cell frequency (p = 0.0011, one-way ANOVA with Tukey’s test) and Treg (CD4+CD25+Foxp3+) cells (p = 0.0119), while reducing Th2 (CD4+IL-4+) (p = 0.0017) and Th17 (CD4+IL-17 A+) (p = 0.0118) subsets, respectively. This evidence concerns the gene IL4 and systemic lupus erythematosus.