Conversely, Pvt1 overexpression (SLE + lenti-Pvt1) showed significantly decreased concentrations of IL-2 (p = 0.0200) and TGF-β (p = 0.0395), along with significantly increased concentrations of IL-6 (p = 0.0124) and IL-17 (p = 0.0044) (Fig. 4A–D). Here, IL2 is linked to systemic lupus erythematosus.