Furthermore, SENP3 alleviated osteoporosis in OVX mice by regulating DLX2/SIRT3 axis.<h4>Conclusion</h4>Addition of SENP3 accelerated osteogenic differentiation and relieved osteoporosis via increasing SIRT3 transcription by the enhance of DLX2 stability via SUMO2/3. This evidence concerns the gene SIRT3 and osteoporosis.