In line with these mechanisms, Mazzu et al. demonstrated that RRM2 downregulation in prostate cancer cells induces widespread transcriptomic and phosphoproteomic changes, including the suppression of key genes enriched in the MYC, E2F and cell cycle pathways and the activation of genes related to the p53 and apoptosis pathways (Mazzu et al. 2019, 2020). This evidence concerns the gene RRM2 and prostate cancer.