To accomplish this, we chose three lung cancer cell lines: squamous cell carcinoma, SKMES1, and two adenocarcinoma cell lines, HCC44 and H838, which all have high PARP7 expression and PARP7 dependency relative to other lung cancer cell lines according to Cancer Dependency Map (DepMap https://depmap.org/). The gene discussed is TIPARP; the disease is squamous cell carcinoma.