Li et al. showed that miR-338-3p overexpressing AD-MSCs exosomes could inhibit chondrocyte inflammation and degradation, as seen by decreased expression of PGE2, IL-6, IL-1β, TNF-α, MMP-3 and MMP-13, as well as by promoting chondrocyte proliferation through targeting RUNX2 [58]. This evidence concerns the gene TNF and Alzheimer disease.