In a similar model, Tofiño-Vian et al. showed that EVs from AD-MSCs reduced inflammation and oxidative stress, mostly through IL-6 and prostaglandin E2, which may mediate anti-senescence effects in OA osteoblasts, seen by the downregulation of senescence-associated β-galactosidase activity and the reduced accumulation of γH2AX foci [53]. Here, IL6 is linked to Alzheimer disease.