NR4A1 and Parkinson disease: NR4A1 is an intracellular transcription factor known to play a key role in inflammatory responses and attenuate oxidative stress in PD models.49 Additionally, NR4A1 is elevated in a 6-OHDA-induced PD rat model, while genetic disruption of NR4A1 induces dopaminergic cell loss in the SN.50 Although several studies have reported associations between NR4A1 and the dopamine system in PD models, our study is the first to investigate the involvement of NR4A1 in selective ER-phagy.