Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by motor symptoms such as rigidity, resting tremor, bradykinesia, and postural instability.1 Pathologically, PD involves the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the presence of Lewy bodies, which are cytoplasmic inclusions primarily composed of aggregated alpha-synuclein (αSyn).2,3 Typically, αSyn exists in a monomeric form4; however, when it aggregates, it disrupts cellular homeostasis, including impairing lysosomal clearance systems.5,6. The gene discussed is SNCA; the disease is Parkinson disease.