Nevertheless, while several molecular mechanisms have been proposed to explain the presence of blood eosinophilia during the blockage of the IL‐4/IL‐13 axis in patients with severe asthma, CRSwNP, and AD, the absence of this phenomenon in chronic obstructive pulmonary disease (COPD) and EoE remains elusive. This evidence concerns the gene IL13 and chronic rhinosinusitis with nasal polyps.