Nevertheless, while several molecular mechanisms have been proposed to explain the presence of blood eosinophilia during the blockage of the IL‐4/IL‐13 axis in patients with severe asthma, CRSwNP, and AD, the absence of this phenomenon in chronic obstructive pulmonary disease (COPD) and EoE remains elusive. The gene discussed is IL4; the disease is eosinophilic esophagitis.