Using serial paraffin‐embedded liver sections from NEPC tumor‐bearing mice, hematoxylin & eosin (H&E, Figure 1b) and immunohistochemical (IHC) staining revealed neural cell adhesion molecule‐1 (CD56, Figure 1c) and synaptophysin (SYP, Figure 1d)‐positive but androgen receptor (AR, Figure 1e)‐negative (CD56+SYP+AR‐) NEPC liver metastatic foci, validating the high penetrance of prostate‐to‐liver metastasis (Figure 1b–e). This evidence concerns the gene NCAM1 and neoplasm.