HMGB1 and eosinophilia-myalgia syndrome: Previous studies have demonstrated extensive M2 macrophage infiltration in the endometriotic pelvis, with these cells playing a critical role in the progression of EMs by promoting cell proliferation, invasion, and neovascularization.[40, 41] In this study, we found that ferroptosis status alterations in EESCs regulated macrophage chemotaxis and polarization through HMGB1.