Further investigations in mice were undertaken by a streptozotocin (STZ)‐induced diabetic model established in Apoe−/− mice, as referenced in previous studies.[5, 18] Diabetic condition exacerbated the accumulation of blood lipids (Figure S2C,E, Supporting Information) and worsened atherosclerosis compared to the control group, as evidenced by increased plaque volume and macrophage infiltration (Figure 1D; Figure S2F,G, Supporting Information). Here, APOE is linked to atherosclerosis.