SIRT1 and central nervous system cancer: A recent study found that SIRT1‐mediated NAD+ consumption induces ferroptosis in gliomas.[37] Conversely, in lung cancer, high doses of NMN were shown to induce ferroptosis, suggesting that elevated NAD+ levels can trigger this process.[38] However, the NMN doses used in the lung cancer study were excessively high—100 to 10 000 times the standard dosage—raising concerns about the objectivity of the results and limiting their clinical relevance.