CTLA4 and lymphoma: Similarly in another study of NKTCL, LMP1+ malignant NK cells exhibited the most intensive immunosuppressive interaction of CD86-CTLA4 and PDL1-PD1 with T cells, correlating with unfavorable prognosis.37 Here, we uncovered that baseline TLG was closely related to the lymphoma microenvironment and immune status in NKTCL.