Similarly in another study of NKTCL, LMP1+ malignant NK cells exhibited the most intensive immunosuppressive interaction of CD86-CTLA4 and PDL1-PD1 with T cells, correlating with unfavorable prognosis.37 Here, we uncovered that baseline TLG was closely related to the lymphoma microenvironment and immune status in NKTCL. This evidence concerns the gene PDLIM7 and extranodal nasal NK/T cell lymphoma.