This phenotype, characterized by long‐lived and proliferative potential, is critical for maintaining CAR T cell activity over extended periods.[48, 49] Furthermore, CXCL13 CAR T cells display improved mitochondrial function, supporting their metabolic fitness and resistance to exhaustion in the TME.[50, 51] Interestingly, while previous studies suggest that CXCL13 can promote tumor cell proliferation and survival in vitro,[52] our CXCL13 CAR T cells demonstrate reduced apoptosis and increased proliferative potential. Here, CXCL13 is linked to neoplasm.