CD274 and neoplasm: Moreover, ionizing radiation in RT not only directly kills cancer cells but also triggers immunogenic cell death (ICD), leading to the release of damage‐associated molecular patterns (DAMPs), promoting dendritic cell maturation, and activating anti‐tumor immune responses.[22] Despite these benefits, it cannot be ignored that RT can induce tumor cells to overexpress PD‐L1 and reduce the anti‐tumor effect of T cells.