B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion molecule (CD155), which enhancing natural killer cell‐mediated cytotoxicity and reshaping the tumor immune microenvironment in vitro and in vivo. The gene discussed is CD80; the disease is glioblastoma.