TNFSF11 and leukemia: Previous studies have shown that PIN has pro‐apoptotic activity, with 100 μm PIN promoting AMPKα phosphorylation, leading to leukemia cell death.[21] In contrast, our study found that 10 or 50 μm PIN could alleviate LPS and RANKL‐induced cell death and IL‐1β release in BMDMs, suggesting that the biological effects of PIN are concentration‐dependent.