Previous studies have shown that PIN has pro‐apoptotic activity, with 100 μm PIN promoting AMPKα phosphorylation, leading to leukemia cell death.[21] In contrast, our study found that 10 or 50 μm PIN could alleviate LPS and RANKL‐induced cell death and IL‐1β release in BMDMs, suggesting that the biological effects of PIN are concentration‐dependent. Here, IL1B is linked to leukemia.