GRK2 and cardiovascular disorder: In addition to its canonical role in GPCR desensitization, GRK2 can catalyze the phosphorylation of various substrates, contributing to broader cellular signaling processes.[8] GRK2 has emerged as a key player in cellular signal transduction and cardiovascular diseases.[9] However, whether GRK2 plays a role in OSS‐induced endothelial inflammation and energy metabolism dysfunction is unknown.