By using classic markers, each cluster was verified to be a distinct cell population: B cells (expressing MS4A1 and CD79B), cancer cells (expressing KRT18 and KRT8), endothelial cells (ECs; expressing PECAM1 and VWF), cancer‐associated fibroblasts (CAFs, expressing DCN and LUM), mural cells (expressing RGS5 and TAGLN), myeloid cells (expressing LYZ and CD68), natural killer cells (NKs; expressing KLRD1 and XCL1), plasma cells (expressing JCHAIN and MZB1), proliferation cells (expressing MKI67 and TOP2A), and T cells (expressing CD3D and TRBC2) (Figure 1C; Figure S1E, Supporting Information). This evidence concerns the gene TOP2A and cancer.