VEGFC and neoplasm: Tumor cells can move toward and infiltrate lymphatic vessels by detecting the chemokine gradients generated by endothelial and myeloid cells.[7, 8] Additionally, VEGF family members (VEGFA, VEGFB, VEGFC, and VEGFD) secreted by tumor and stromal cells can promote lymphangiogenesis, thereby increasing pathways to lymphatic vessels.[9, 10, 11, 12] Furthermore, the transformation of the LN microenvironment by tumor cells is also a vital aspect.