UXT and amyotrophic lateral sclerosis: Moreover, because protein misfolding and aggregation are central to numerous degenerative disorders—including Alzheimer’s 12–14, Huntington’s 15, 16, and amyotrophic lateral sclerosis 14, 17—it will be intriguing to test whether the UXT and UFD1 strategies developed here can be adapted for neurodegenerative conditions beyond the retina.