The levels of VAP-1 were significantly elevated in a variety of chronic diseases including NASH, chronic hepatitis B/C infection, and primary sclerosing cholangitis, their levels are associated with progressive liver fibrosis (Kraemer et al., 2019; Öksuz et al., 2020), representing a biomarker for monitoring the severity of fibrosis. The gene discussed is AOC3; the disease is sclerosing cholangitis.