Furthermore, the dedifferentiated LSECs can also secrete profibrogenic molecules such as transforming growth factor-β (TGF-β), fibronectin, laminin, VAP-1 and adhesion molecules (ICAM-1, VCAM-1) to directly activate HSCs to accelerate the progression of liver fibrosis. The gene discussed is TGFB1; the disease is Hepatic fibrosis.