MMP-2, MMP-9, and ADAM17 have been implicated in the degradation of the endothelial barrier, leading to the increased permeability of the endothelium and the recruitment of inflammatory cells, which further promotes progression of vascular remodeling and hypertension (Merchant and Davidge, 2004; Prado et al., 2021). The gene discussed is MMP2; the disease is hypertensive disorder.