IL1B and atherosclerosis: The ADAM family, especially ADAM10 and ADAM17, has been implicated in the shedding of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) (Figure 4), which exacerbate the inflammatory response in atherosclerosis (Raffetto and Khalil, 2008).