The expression of circRNA-0018553 is decreased in Ang II-treated cardiomyocytes, but it is enriched in endothelial progenitor cell-derived exosomes. Transplanting these exosomes into cardiomyocytes will alleviate Ang II-induced cardiac hypertrophy via miR-4731 targeting to SIRT2. This evidence concerns the gene SIRT2 and cardiac hypertrophy.