Similarly, exosomes circulating after MI carry lncRNA TUG1, which can downregulate angiogenesis by dysfunction of the HIF-1α/VEGF-α axis, and this phenomenon is also confirmed by a randomized controlled trial of post-MI patients, who will receive or not receive percutaneous coronary intervention (Dang et al., 2023). The gene discussed is HIF1A; the disease is myocardial infarction.