MYC and neoplasm: Additionally, we observed significant enrichment of multiple oncogenic pathways—including HIPPO, MYC, NOTCH, RTK-RAS, TGF-β, and WNT—in the high TELscore group, whereas TP53-related tumor-suppressive signaling was more prevalent in the low TELscore group (Kastenhuber and Lowe, 2017).