Additionally, a biomarker of Any Genomic Instability (AGI) biomarker (defined by high homologous recombination deficiency (HRD) and/or TP53 Mutant-like signatures; vs. No Genomic Instability markers), was associated with Adaptive immune class in previous work12, and was associated with high lymphocyte count [OR =2.6 (95% CI [1.9, 3.3])] but less strongly associated with high proximity and consistency, with odds ratios that were not significant at the 95% confidence level. The gene discussed is TP53; the disease is hypoparathyroidism-retardation-dysmorphism syndrome.