HES1 and psoriasis: Notch signaling, via hes family bHLH transcription factor 1 (Hes1), regulates skin aging by mitigating cellular senescence and inflammation in fibroblasts, while hes1 dysfunction in psoriasis disrupts the protein phosphatase axis, with hes1 restoration alleviating inflammation in keratinocytes (Z. Wang et al. 2022; Zou et al. 2021).