It was reported that peimine exhibits anti‐inflammatory effects in the treatment of osteoarthritis and asthma, primarily by inhibiting inflammatory factors such as interleukin‐1β, NF‐κB, and tumor necrosis factor α‐mediated inflammation via the mitogen‐activated protein kinase (MAPK) pathway, thereby playing a therapeutic role (Chen et al. 2019; Peng et al. 2023; Zhou et al. 2022). The gene discussed is NFKB1; the disease is osteoarthritis.